tags-40783

更新时间:2022-08-06 07:58:50

【Cep

CEP-40783用途 CEP-40783是高效选择性,有口服活性的AXL和c-Met抑制剂,IC50值分别为7 nM 和12 nM。 产品性质 图谱 CEP-40783名称 CEP-40783生物活性 CEP-40783物理化学性质 CEP-40783英文别名 N- {4- [ (6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl}-3- (4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide。

CEP

CEP-40783 产品编号 T4426 CAS 1437321-24-8 别名: CEP-40783 (RXDX-106), CEP40783, CEP 40783, RXDX-106, 化合物CEP40783, RXDX-106, CEP40783, CEP 40783。

美国GlpBio

CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively. In AXL-transfected 293GT cells, CEP-40783 is 27-fold more active compared to recombinant enzyme with an IC50 value 美国GlpBio 。

CEP-40783 - c-Met/HGFR | TAM Receptor

CEP-40783 is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).。

CEP

CEP-40783. RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM (TYRO3, AXL, MER)/MET inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively. Store at -20℃ for one year(Powder);Store at 2-4 。

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40783

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CEP40783 - TAM Receptor;c-Met/HGFR

CEP-40783 is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM). In vitro. In AXL-transfected 293 gT cells, CEP-40783 is 27-fold more active compared to the recombinant enzyme (IC50: 0.26 nM). In GTL-16 cells, CEP-40783 also has superior activity against c-Met (IC50: 6 。

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